ABSTRACT
Several new pyrazolopyridines VIa-c were synthesized by reacting 4-nitrosoantipyrine [IIa] with arylidenemalononitriles Ia-c or ethyl arylidenecyanoacetates If-h. Reaction of Ia-c with 4-[azidomethylcarbonyl] antipyrine [IIb] afforded the pyridine derivatives XVI. The 4H-pyrans and naphthodipyran derivatives XVIII- XXI were prepared by reacting I with polyhydric phenols
Subject(s)
Pyrazoles/analogs & derivatives , Pyrans/analogs & derivatives , Heterocyclic Compounds/chemical synthesis , Pyridines/chemical synthesis , Pyrazoles/chemical synthesis , Pyridines/chemical synthesisABSTRACT
Several new modified estradiol analogs have been synthesized and examined as potential estrogens. Nuclear modification involved the introduction of various substituents at the 2-position of estradiol and fusion of a heterocylic ring to position 2, 3 of ring A of the steroidal nucleus. Uterine weight assays in rats have shown that all tested compounds produced a moderate increase in uterine weight